How it works

The alginate sheet is implanted to bridge the gap in the injured nerve. The alginate turns to gel form following absorption of water, creating the optimal environment for nerve regeneration to take place. The gel protects the nerve endings from highly proliferative fibroblasts.

The alginate begins resorbing gradually from the surface area towards the center and together with the PGA mesh, continues to promote/facilitate nerve regeneratin across the gap.
Schwann cells migrate from both nerve endings, while axons grow from the proximal stump along the surface area where the alginate has been resorbed.

The alginate gel continues to resorb towards the center. The axons from the proximal stump continue to grow and enter the distal stump, being led by Schwann cells.

After the gel has fully resorbed, the regenerated axons continue to grow, joining the two nerve endings. By 26 weeks the PGA mesh has also fully resorbed.